Duo Biotic Toothpaste
Duo Biotic Toothpaste
The first and only toothpaste with S. Dentisani 7746, a powerful postbiotic and a concentration of its natural peptides.
A toothpaste formulated with powerful pre + post biotics found naturally in healthy mouths and clinically studied to support optimal oral health. Expect a gentle foam and mint forward taste within a nourishing, synergistic base. Formulated with no artificial flavorings, color or preservatives and no harsh surfactants (SLS). Designed to work with your biology, not against it.
Fluoride Free
Clinically Studied
Dentist Formulated
Free delivery from $40
30-day returns
Clinically studied strain
Fluoride-free, hydroxyapatite
Inhibits bad breath and plaque
Clean-certified
How to use
How to use
Brush morning and night, exactly as you do now. Use a pea-sized amount, brush for two minutes, then spit instead of rinsing heavily so the strain stays in contact with your teeth. That's the whole routine. No new steps, just a formula that works with your mouth instead of against it.
When you'll notice it
When you'll notice it
Duo Biotic works gradually, because it's rebalancing an ecosystem rather than masking a symptom. Most people notice a fresher, cleaner-feeling mouth in the first couple of weeks. The strain colonises over the first month, and the fuller shift toward a balanced microbiome builds over roughly eight weeks of consistent use. Consistency matters more than intensity, which is why most people start on the 3-month supply.
What's in it, what's not
What's in it, what's not
In: S. dentisani 7746, the protective strain. L-Arginine, its prebiotic fuel. Hydroxyapatite, for fluoride-free enamel support.
Not in: fluoride, SLS, or the harsh antimicrobials in most toothpaste that strip the good bacteria along with the bad. Vegan, and safe to swallow.
How the subscription works
How the subscription works
Your first order ships in full. After that, refills arrive automatically on the cadence you choose, so you never run out mid-routine, which is when most people lose the progress they've built. Pause, skip, reschedule or cancel anytime from your account. No lock-in, no fees.
Oral care spent 100 years killing bacteria.
Your mouth needs the opposite.
We don't kill the microbiome. We optimize it, with S. dentisani 7746, made to work for you. Good bacteria protect your mouth. We help them win. Balance is the point. It's even in the name.
Your mouth is a microbiome, the second-largest in your body. Conventional toothpaste strips the good bacteria along with the bad. When you sterilize your mouth the bad bacteria colonizes more quickly than the good creating dysbiosis.
Imbalance is the real problem, most oral health problems (cavities, bad breath, inflammation, etc) begin when that ecosystem falls out of balance.
Backed by clinical research on the probiotic strains in our formula (Nart et al., Journal of Clinical and Experimental Dentistry, 2021), shown to colonise the mouth and support a balanced oral microbiome.
Duo Biotic.
Three jobs, every brush.
Crowds out harmful bacteria
14 naturally occurring antimicrobial peptides target harmful pathogens while leaving the good bacteria intact.
Buffers acid after meals
L-Arginine, a naturally occurring amino acid in saliva, helps neutralize acid and supports a clean, fresh-feeling mouth.
Calming
Supports your gums' natural IL-10 response — soothing
and calming right at the gum line.
S. Dentisani 7746: the strain that restores your oral microbiome.
Over one month, the strain improved every marker below — less plaque, healthier saliva flow, a healthier microbiome shift, and better acid buffering.
Less plaque
vs placebo
Healthier saliva flow¹
significantly higher
Healthier microbiome shift¹
fewer cavity bacteria
Better acid buffering¹
raised calcium
The only toothpaste that restores your microbiome.
No conventional or "natural" toothpaste does what this does.
Others
"Natural"
Restores beneficial bacteria
Contains S. dentisani strain
Exclusive to Evenmouth
Clinically studied strain
Rare
Buffers acid after meals
Fluoride-free + hydroxyapatite
Some
14 antimicrobial peptides
Exclusive to Evenmouth
Prof. Hatice Hasturk, DDS
Dr. Alex Mira
Dr. Thomas Van Dyke
Dr. Brett Kessler
Dr. Aruna Rao, DDS, MS
Dr. Diana Thiara, MD, MS
Dr. Avo Samuelian
Anne O. Rice, RDH
Every ingredient has a job.
Three research-backed actives, each doing one thing for your mouth's ecosystem. No artifical flavors, ingredients or preservitives, no harsh detergents.
A naturally occurring biotic found in healthy mouths, Streptococcus Dentisani and its bioactive peptides help shape and support a healthy oral ecosystem.
Benefits
- supports optimal oral health and microbial balance
- 14 naturally occuring antimicrobial peptides
- Targets bad bacteria only that cause bad breath and plaque
An amino acid naturally present in saliva. It is the prebiotic half of the Duo: it feeds S. dentisani and powers the pathway that keeps your mouth's pH in balance.
Benefits
- Fuels the strain so it colonises and stays active
- Buffers the acid that erodes enamel after meals
- Supports healthy enamel
Glycerin, Hydrated Silica, Water, Xylitol, L-Arginine, Lauryl Glucoside, Hydroxyapatite, Streptococcus Dentisani 7746, Natural Flavor, Xanthan Gum, Stevia Rebaudiana Leaf/Stem Extract
We're serious about facts. Ask away.
Yes! While fluoride has historically been the standard for proven remineralization, hydroxyapatite is a proven alternative for those that prefer fluoride-free. We use a biomimetic form, micro hydroxyapatite that sourced from Italy
It's a specific oral strain, delivered where it colonizes. A gut probiotic won't survive or settle in your mouth. Different bacteria colonize in different environments.
The microbiome science in Duo Biotic is relatively new and exciting! S. dentisani 7746 was discovered and studied over the past ten years. It's a breakthrough in oral health.
from the first brush you'll notice a satisfying, fresh, clean feeling. The pre+post biotic formulation goes to work immediately to start improving your oral microbiome to a better balanced state. In the first weeks you'll notice a cleaner feeling mouth and fresh breath. After extended use don't be surprised by affirmation at your next dental check up.
